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CASE 2: Multiple Myeloma - 9/8/00
QUIZ 2.2 - ANSWERS
1. 1% of myeloma patients do not secrete a paraprotein (M component)
and therefore do not satisfy all 3 diagnostic criteria.
2. Any of the three tests listed below are acceptable:
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Immunofixation
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Immunoelectrophoresis
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Western blotting
3. Any two of the following cytokines:
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TNF-a: Activates osteoclasts and inhibits EPO production (either function
accepted)
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IL-1: Activates osteoclasts
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IL-6: Promotes myeloma cell growth
4. Reduced antibody production
Neutropenia
5. *You should recognize that the half life is dependent on concentration
and might be unchanged or shorter than normal (3 weeks).
*Either (C) or (D) is acceptable.
*It is not likely that the half life would be as short as 3 days.
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