Medical Microbiology 850
QUIZ 3 (10 points) - September 15, 2000
Case 3: Drug Allergies - Michael Parmely, Ph.D.

1. Any two of the following:

  • Histamine. Drug blocks histidine conversion to histamine
  • Prostaglandins and leukotrienes. Drug inhibits PLA2
  • Cytokines. Drug inhibits NF-kb and blocks cytokine gene expression (e.g., IL-1, TNF-a).

    • 2. Epinephrine or anti-histamines (e.g. diphenhydramine)

    3. Coombs test

    4. Performed:

  • histamine
  • ECF-A
  • NCF-A
  • heparin
  • tryptase
  • chymase


    • Newly synthesized:

  • PAF
  • leukotrienes
  • prostaglandins
  • cytokines (TNF-a, IL-1, IL-3, IL-4)

    • Last modified: April 12, 2003