Lecture 1: DNA,
Genes, Chromatin
8/29/05
Dr. J. Calvet, 6001B WHE,
588-7424, email: jcalvet@kumc.edu
Reading Assignment:
Nussbaum, R.L. et al. "Thompson & Thompson Genetics in
Medicine," 6th edition (Revised Reprint), Saunders, 2004.
Chapters 1- 6;
Clinical Cases: Familial Hypercholesterolemia, Xeroderma Pigmentosum, Hemophilia,
Thalassemia,
I-Cell Disease, p. 215; Telomerase pp. 318-320.
Baynes, J. and Dominiczak, M.H. "Medical Biochemistry,"
(2nd edition) Mosby, 2004. Chapters 29-33.
Internet Resources:
Online Mendelian Inheritance in Man (http://www3.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM)
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Learning
Objectives for Lecture 1:
- Understand the structure of DNA, including the
structure of the bases, nucleosides, nucleotides, and the structure of the DNA double
helix
- Understand the significance of the specificity of
base pairing and the complementarity of the DNA strands
- Understand the nature of the forces contributing to
the stability of the DNA double helix
- Understand the process of DNA denaturation and the
relationship between melting temperature and the base composition of DNA
- Understand the
principles of the DNA reassociation
reaction
- Understand the relationship between the rate of DNA
reassociation and DNA complexity
- Understand what repetitive sequences are and how
they are arranged in the human genome
- Understand the mechanism by which Alu sequences have
affected the LDL receptor gene
- Understand basic gene structure and the basic
characteristics of human nuclear and mitochondrial DNA
- Understand basic chromosome structure and how DNA is
packaged into chromosomes
- Understand the significance of
telomeres to aging and cancer and the use of telomerase
in cancer diagnosis
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Move forward to: Lecture 2
Lecture 3
Lecture 4
Session 5
Lecture 6
Lecture 7
Lecture 8
Session 9
Lecture 10
Molecular and Human
Genetics
Learning Objectives
Lectures - Fall 2005
Lectures - Spring 2006
Internet Research Assignment
 Medical Biochemistry |