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Nussbaum, R.L. et al. "Thompson & Thompson Genetics in Medicine," 6th edition (Revised Reprint), Saunders, 2004. Chapters 1- 6; Clinical Cases: Familial Hypercholesterolemia, Xeroderma Pigmentosum, Hemophilia, Thalassemia, I-Cell Disease, p. 215; Telomerase pp. 318-320.

Baynes, J. and Dominiczak, M.H. "Medical Biochemistry," (2nd edition) Mosby, 2004. Chapters 29-33.

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Learning Objectives for Lecture 2:

Understand the general mechanism of DNA replication
Understand the need for a primer for DNA replication
Understand the dynamics of DNA strand synthesis on the leading and lagging strands of the replication fork
Understand the general functions of the proteins involved in DNA replication at the replication fork
Understand the role of DNA gyrase in DNA replication and know the class of antibiotics that inhibits this enzyme
Understand the types of mutations and the rates with which DNA is mutated
Understand the mechanism by which mutations are generated
Understand the basic types of DNA repair and when they take place
Understand the reason for 5'-mCpG mutation hot spots in DNA
Understand the significance of high fidelity DNA replication and for the presence of DNA repair mechanisms for cellular function and for human disease

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Molecular and Human Genetics
     Learning Objectives
     Lectures - Fall 2005
     Lectures - Spring 2006
     Internet Research Assignment

Medical Biochemistry

Lecture 2: DNA Replication, Mutation, Repair

8/29/05