Microsoft PowerPoint Presentation

Nussbaum, R.L. et al. "Thompson & Thompson Genetics in Medicine," 6th edition (Revised Reprint), Saunders, 2004. Chapters 1- 6; Clinical Cases: Familial Hypercholesterolemia, Xeroderma Pigmentosum, Hemophilia, Thalassemia, I-Cell Disease, p. 215; Telomerase pp. 318-320.

Baynes, J. and Dominiczak, M.H. "Medical Biochemistry," (2nd edition) Mosby, 2004. Chapters 29-33.

Internet Resources:

Click here to download PowerPoint images for Lecture 3
If you download in Microsoft Internet Explorer, right click on the first slide of the lecture and click on "Edit Slides" to get into PowerPoint to see the notes as well as the slides.

Learning Objectives for Lecture 3:

Compare and contrast the chemistry of DNA and RNA
Know the major classes of RNA in prokaryotes
Understand the structure of prokaryotic mRNA
Understand the structure of the prokaryotic promoter
Understand the structure of bacterial RNA polymerase and know the class of antibiotics that inhibits this enzyme
Understand the function of the sigma factor in the initiation of transcription in E. coli
Understand the mechanism of regulation of transcription of the lac operon - the roles of positive and negative regulation
Understand the roles of the allosteric effectors, allolactose and cAMP in the regulation of the lac operon

Return to:

Lecture 1
Lecture 2

Move forward to:

Lecture 4
Session 5
Lecture 6
Lecture 7
Lecture 8
Session 9
Lecture 10

Molecular and Human Genetics
     Learning Objectives
     Lectures - Fall 2005
     Lectures - Spring 2006
     Internet Research Assignment

Medical Biochemistry

Lecture 3: RNA Structure and Transcription

8/31/05