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Nussbaum, R.L. et al. "Thompson & Thompson Genetics in Medicine," 6th edition (Revised Reprint), Saunders, 2004. Chapters 1- 6; Clinical Cases: Familial Hypercholesterolemia, Xeroderma Pigmentosum, Hemophilia, Thalassemia, I-Cell Disease, p. 215; Telomerase pp. 318-320.

Baynes, J. and Dominiczak, M.H. "Medical Biochemistry," (2nd edition) Mosby, 2004. Chapters 29-33.

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Learning Objectives for Lecture 4:

Know the major classes of RNA in eukaryotes, their RNA polymerases, and what inhibits RNA polymerase II
Understand the structure of eukaryotic mRNA
Understand the structure of the eukaryotic promoter
Understand the fact that mRNAs exist in different abundance classes and that these differences are due largely to transcriptional regulation
Understand how the preinitiation complex forms
Understand the role of transcription factors and how they bind transcription response elements in DNA
Understand the structure and function of the bZIP transcription factors
Understand the structure and function of the zinc finger transcription factors belonging to the nuclear receptor superfamily of transcription factors
Understand how mutations can affect the function of the factor IX promoter

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Molecular and Human Genetics
     Learning Objectives
     Lectures - Fall 2005
     Lectures - Spring 2006
     Internet Research Assignment

Medical Biochemistry

Lecture 4: Eukaryotic Transcriptional Regulation

9/1/05