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Nussbaum, R.L. et al. "Thompson & Thompson Genetics in Medicine," 6th edition (Revised Reprint), Saunders, 2004. Chapters 1- 6; Clinical Cases: Familial Hypercholesterolemia, Xeroderma Pigmentosum, Hemophilia, Thalassemia, I-Cell Disease, p. 215; Telomerase pp. 318-320.

Baynes, J. and Dominiczak, M.H. "Medical Biochemistry," (2nd edition) Mosby, 2004. Chapters 29-33.

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Learning Objectives for Lecture 7:

Understand the structure of the ribosome and polysome
Understand the role of tRNA as an "adaptor"
Understand the mechanism for charging tRNAs
Understand the general characteristics of the genetic code
Know the start and stop codons
Understand the mechanism for how some tRNAs can recognize more than one codon
Understand how the AUG initiation codon is recognized in prokaryotes and eukaryotes
Understand how the AUG codon establishes the reading frame
Know the various kinds of mutations that affect the translation of proteins

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Molecular and Human Genetics
     Learning Objectives
     Lectures - Fall 2005
     Lectures - Spring 2006
     Internet Research Assignment

Medical Biochemistry

Lecture 7: Protein Synthesis and the Genetic Code

9/7/05