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Nussbaum, R.L. et al. "Thompson & Thompson Genetics in Medicine," 6th edition (Revised Reprint), Saunders, 2004. Chapters 1- 6; Clinical Cases: Familial Hypercholesterolemia, Xeroderma Pigmentosum, Hemophilia, Thalassemia, I-Cell Disease, p. 215; Telomerase pp. 318-320.

Baynes, J. and Dominiczak, M.H. "Medical Biochemistry," (2nd edition) Mosby, 2004. Chapters 29-33.

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Learning Objectives for Lecture 8:

Understand the structure of the ribosome in the context of the translation process
Understand the steps in the initiation of protein synthesis
Understand the mechanism of peptide bond formation, and that it is RNA catalyzed
Understand the processes of elongation and termination
Understand how interferon inhibits viral protein synthesis
Understand the mechanisms by which antibiotics inhibit protein synthesis and how some organisms become resistant to antibiotics
Understand how secreted and membrane-bound proteins are synthesized
Understand how proteins are glycosylated and what the functions of the carbohydrates are
Understand the role of proteolytic processing in protein maturation

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Molecular and Human Genetics
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     Lectures - Fall 2005
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Medical Biochemistry

Lecture 8: Protein Synthesis and Protein Processing

9/8/05