Representative Publications: James Calvet

Puri, S., Rodova, M., Islam, R.M., Magenheimer, B.S., Maser, R.L., and Calvet, J.P. (2006) Ets factors regulate the polycystic kidney disease-1 (PKD1) promoter. Biochem. Biophys. Res. Comm. 342:1005-1013.

Puri, S., Magenheimer, B.S., Maser, R.L., Ryan, E.M., Zien, C.A., Walker, D.D., Wallace, D.P., Hempson, S.J., and Calvet, J.P. (2004) Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway. J. Biol. Chem. 279:55455-55464.

Yamaguchi, T., Wallace, D.P., Magenheimer, B.S., Hempson, S.J., Grantham, J.J., and Calvet, J.P. (2004) Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J. Biol. Chem. 279:40419-40430.

Le, N.H., van der Bent, P., Huls, G., van de Wetering, M., Loghman-Adham, M., Ong, A.C., Calvet, J.P., Clevers, H., Breuning, M.H., van Dam, H., and Peters, D.J. (2004) Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected. J. Biol. Chem. 279:27472-27481.

Rodova, M., Islam, M.R., Peterson, K.R. and Calvet, J.P. (2003) Remarkable sequence conservation of the last intron in the PKD1 gene. Molec. Biol. Evol. 20:1669-1674.

Maser, R.L., Magenheimer, B.S., Zien , C.A. and Calvet, J.P. (2003) Transient transfection assays for analysis of signal transduction in renal cells. In Methods in Molecular Medicine, Renal Disease Techniques and Protocols. Vol. 86, pp. 205-217, M.S. Goligorsky, ed. Humana Press, Totowa , N.J. (methods chapter).

Calvet, J.P. (2003) Ciliary signaling goes down the tubes. Nature Genetics 33:113-114. (news & views).

Calvet, J.P. (2003) New insights into ciliary function: kidney cysts and photoreceptors. Proc. Nat. Acad. Sci. USA 100:5583-5585. (invited commentary).

Calvet, J.P. (2002) Cilia in PKD - Letting it all hang out. J. Am. Soc. Nephrol. 13:2614-2616. (invited editorial review).

Rodova, M., Islam, M.R., Maser, R.L. and Calvet, J.P. (2002)  The polycystic kidney disease-1 promoter is a target of the beta-catenin/T-cell factor pathway. J. Biol. Chem. 277:29577-29583.

Wolf, D., Rodova, M., Miska, E.A., Calvet, J.P. and Kouzarides, T. (2002) Acetylation of beta-catenin by CREB-binding protein (CBP). J. Biol.Chem.  277:25562-25567.

Ledford, A.W., Brantley, J.G., Kemeny, G., Foreman, T.L., Quaggin, S.E., Igarashi, P., Oberhaus, S.M., Rodova, M., Calvet, J.P., and Vanden Heuvel, G.B. (2002) Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in down regulation of p27kip1 expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia. Dev. Biol.  245:157-171.

Parnell , S.C. , Magenheimer, B.S., Maser, R.L., Zien , C.A. , Frischauf, A. and Calvet, J.P. (2002)  Polycystin-1 activation of c-Jun-N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins.  J. Biol. Chem. 277:19566-19572.

Maser, R.L., Vassmer, D., Magenheimer, B.S. and Calvet, J.P. (2002)  Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease.  J. Am. Soc. Nephrol. 13:991-999.

Calvet, J.P. and Grantham, J.J. (2001)  The genetics and physiology of polycystic kidney disease.  Sem. Nephrol. 21:107-123.

Grantham, J.J. and Calvet, J.P. (2001) Polycystic kidney disease: In danger of being X-rated?  Proc. Natl. Acad. Sci.  USA 98:790-792.

Sutters, M., Yamaguchi, T., Maser, R.L., Magenheimer, B.S., St. John , P.L., Abrahamson, D.R., Grantham, J.J. and Calvet, J.P. (2001) Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells.  Kidney Int. 60:484-494.

Ricker, J.L., Gattone, V.H., Calvet, J.P. and Rankin , C.A. (2000)  Development of autosomal recessive polycystic kidney disease in Balb-c cpk/cpk mice.  J. Am. Soc. Nephrol.  11:1837, 1847.

Parnell , S.C. , Magenheimer, B.S., Maser, R.L. and Calvet, J.P. (1999)  Identification of the major site of in vitro PKA phosphorylation in the polycystin-1 C-terminal cytosolic domain.  Biochem. Biophys. Res. Comm.  259:539-543.

Rankin , C.A. , Itoh, Y., Tian, C., Ziemer, D.M., Calvet, J.P. and Gattone, V.H. (1999) Matrix metalloproteinase 2 in a murine model of infantile polycystic kidney disease. J. Am. Soc. Nephrol. 10:210-217.

Parnell , S.C. , Magenheimer, B.S., Maser, R.L., Rankin , C.A. , Smine, A., Okamoto, T. and Calvet, J.P. (1998) The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro. Biochem. Biophys. Res. Comm. 251:625-631.

Witzgall, R., Obermuller, N., Bolitz, U., Calvet, J.P., Cowley, B.D., Walker, C., Kriz, W., Gretz, N. and Bonventre, J.V. (1998) Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia. Am. J. Physiol. 275:F928-F937.

Rankin, C.A., Suzuki, K., Itoh, Y., Ziemer, D.M., Grantham, J.J., Calvet, J.P. and Nagase, H. (1996) Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules. Kidney Int. 50:835-844.

Rankin, C.A., Ziemer, D.M., Maser, R.L., Foo, I. and Calvet, J.P. (1996) Growth characteristics and gene expression in cultured cells from two murine models of polycystic kidney disease. In Vitro Cell. Dev. Biol. 32:100-106.

Hou, X., Maser, R.L., Magenheimer, B.S. and Calvet, J.P. (1996) A mouse kidney- and liver-expressed cDNA having homology with a prokaryotic parathion hydrolase (phosphotriesterase) gene: abnormal expression in injured and polycystic kidneys. Gene 168:157-163.

Gattone, V.H., Kuenstler, K.A., Lindemann, G.W., Lu, X., Cowley, B.D., Rankin, C.A. and Calvet, J.P. (1996) Renal expression of a transforming growth factor alpha transgene accelerates the progression of inherited, slowly progressive polycystic kidney disease in the mouse. J. Lab. Clin. Med. 127:214-222.

Davidow, C.J., Maser, R.M., Rome , L.A. , Calvet, J.P. and Grantham, J.J. (1996) The cystic fibrosis transmembrane conductance regulator (CFTR) mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease (ADPKD) epithelium in vitro. Kidney Int. 50:208-218.

Maser, R.L. and Calvet, J.P. (1995) Analysis of differential gene expression in the kidney by differential cDNA screening, subtractive cloning, and mRNA differential display. Sem. Nephrol., 15:29-42.

Maser, R.L., Magenheimer, B.S. and Calvet, J.P. (1994) Mouse plasma glutathione peroxidase: cDNA sequence analysis and renal proximal tubular expression and secretion. J. Biol. Chem., 269:27066-27073.

Calvet, J.P. and Chadwick, L.J. (1994) Primary and secondary genetic responses following folic acid-induced acute renal injury in the mouse. J. Am. Soc. Nephrol, 5:1324-1332.

Calvet, J.P. (1994) Injury and development in polycystic kidney disease. Curr. Opin. Nephrol. Hypertens. 3:340-348.

Calvet, J.P. (1993) Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation? Kidney Int. 43:101-108.

Birkenmeier, E.H., Letts, V.A., Frankel, W.N., Magenheimer, B.S. and Calvet, J.P. (1993) Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14. Mammalian Gen. 4:131-132.

Cowley, B.D., Gudapaty, S., Kraybill, A.L., Harding, M.A., Calvet, J.P. and Gattone, V.H. (1993) Autosomal dominant polycystic kidney disease in the rat. Kidney Int. 43:522-534.

Rankin, C.A., Grantham, J.J. and Calvet, J.P. (1992) c-fos expression is hypersensitive to serum-stimulation in cultured cystic kidney cells from the C57BL/6J-cpk mouse. J. Cell. Physiol. 152:578-586.

Harding, M.A., Gattone, V.H., Grantham, J.J. and Calvet, J.P. (1992) Localization of overexpressed c-myc mRNA in polycystic kidneys of the cpk mouse. Kidney Int. 41:317-325.

Takahashi, H., Calvet, J.P., Dittemore-Hoover, D., Yoshida, K., Grantham, J.J. and Gattone, V.H. (1991) A hereditary model of slowly progressive polycystic kidney disease in the mouse. J. Am. Soc. Nephrol. 1:980-989.

Cowley, B.D., Chadwick, L.J., Grantham, J.J. and Calvet, J.P. (1991) Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse. J. Am. Soc. Nephrol. 1:1048-1053.

Harding, M.A., Chadwick, L.J., Gattone and Calvet, J.P. (1991) The SGP-2 gene is developmentally regulated in the mouse kidney and abnormally expressed in collecting duct cysts in polycystic kidney disease. Dev. Biol. 146:483-490.

Calvet, J.P. (1991) Molecular approaches for analyzing differential gene expression: differential cDNA library construction and screening. Pediatr. Nephrol. 5:751-757.

Gattone, V.H., Andrews, G.K., Niu Fu-wen, Chadwick, L.J., Klein, R.M. and Calvet, J.P. (1990) Defective epidermal growth factor gene expression in mice with polycystic kidney disease. Dev. Biol. 138:225-230.

Calvet, J.P. (1990) Molecular biology, gene expression, and medicine. In "Topics in Renal Medicine: Inheritance of Kidney and Urinary Tract Diseases" (Spitzer, A. and Avner, E.D., eds.) Kluwer, Boston, pp. 3-51.

Calvet, J.P. and Cowley, B.D. (1990) Proto-oncogene expression in autosomal recessive polycystic kidney disease. In "Advances in the Pathogenesis of Polycystic Kidney Disease" (Carone, F.A. and Dobbie, J.W., eds.) TP&T, Chicago, pp. 33-36.

Cowley, B.D., Chadwick, L.J., Grantham, J.J. and Calvet, J.P. (1989) Sequential proto-oncogene expression in regenerating kidney following acute renal injury. J. Biol. Chem. 264:8389-8393.

Cowley, B.D. Smardo, F.L., Grantham, J.J. and Calvet, J.P. (1987) Elevated c-myc proto-oncogene expression in autosomal recessive polycystic kidney disease. Proc. Natl. Acad. Sci. USA 84:8394-8398.